First off, for Pete, the Guys discuss what they would do if they could clone themselves. What follows is a largely on topic conversation about the perils of cloning yourself, Multiplicity, Madrox (you know, Multiple Man from Marvel Comics), and why Dave isn't sure he should have a baseball team made of Daves.
Second, for Drew, the Guys talk about their favorite jobs (outside of the nuclear plant) that Homer has had throughout all of the seasons of The Simpsons. This conversation is exactly what you think it is going to be: a pile of references and jokes from episodes, and a discussion of things as wide ranging as the Naval Reserve, and "Homie the Clown".
Lastly, Sam laid out a challenge for the guys to build their ideal sandwich (as had been mentioned in a previous episode), so the guys spend a good chunk of time discussing amazing sandwiches, their time at the University (as it pertains to sandwiches), and the intricacies of mustard.